Also known as ED and impotence, the loss of the ability to produce and/or sustain an erection despite adequate stimulation and interest.
Physiology of Erection
The penis is made up of 3 chambers, two corpora cavernosa – the erectile tissues and one corpus spongium. Secretion of nitric oxide (NO) leads to sexual arousal, blood vessels dilate and blood fills the penis. This typically lasts until arousal is diminished or orgasm is achieved.
Penile erection is mediated by the nervous system. On stimulation causes vasodilatation and relaxation of the cavernosal (penis) smooth muscle, which ultimately leads to penile erection. Nitric oxide is released from nerve endings by activating guanylate cyclase and resulting into cGMP which is the secondary messenger that causes smooth muscles relaxation leads to venous engorgement and penile tumescence.
Recent research has helped to change our thinking about the most common causes of sexual dysfunction. For a long time it was assumed that almost all erection failures were caused by psychological factors -- stress, anxiety, and fear. While these factors can play a significant role, most experts now believe the major cause of impotence is physical. Simply stated, anything that interferes with blood flow to the sexual organs interferes with sexual function.
It was presumed that almost all erection failures were caused by physiological factors like stress, fear, anxiety etc. Though these factors play a significant role, recent researches also indicate impotence as physical inability of blood flow to the penis.
Physical causes of erectile dysfunction
* Excess use of alcohol and tobacco/nicotine
* Brain or spinal-cord injuries
* Low testosterone levels i.e. Hypogonadism
* Parkinson's disease
* Radiation therapy to the testicles
* Heart stroke/s
* Some types of prostate or bladder surgery
* Hyperglycemia (high blood sugar)
* Hypertension (high blood pressure)
Feelings that can lead to erectile dysfunction
* Nervousness about sex. It could be a result of bad experience or past episode of impotence.
* Stress related to work/family
* Problems in the relation with sex partner
* Consciousness and negative feelings
Testosterone and Sex Drive
As age increases, men usually suffer from low sex drive, poor stamina and lack of sexual interest, because most of the testosterone gets bound by sex hormone building globulin. Only 2% of testosterone are left free which are responsible for providing the body with energy and sex drive. Normal men should have 800 free testosterone and lesser number calls for erectile dysfunction.
Xanthoparmelia Scabrosa: The Xanthoparmelia Scabrosa lichen is a natural PDE-5 inhibitor, allowing for sustained erections (works like Viagra). PDE-5 breaks down cGMP. cGMP is what is required to get an erection, therefore if you can inhibit PDE-5 you will have more cGMP, and harder erections.
Cnidium Monnier extract: This herb Boosts levels of Cyclic Guanosine Monophosphate (cGMP). cGMP relaxes the muscles around the penis, making it possible for the penis to take in blood, thus allowing you to experience a proper erection. Cnidium Monnier is also known to be a powerful aphrodisiac.
Piperine: It's been scientifically proven that this particular extract of black pepper will enhance the body’s adsorption, of certain nutrients, such as those in the Niagra formula. Piper nigrum inclusion is to increase the speed at which the herbs start working and help with maximum herbal adsorption of the herbs, making the finished product more effective.
L-Arginine: L-arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation), such as atherosclerosis, erectile dysfunction, and intermittent claudication.
Piper nigrum extract: Its been scientifically proven that this particular extract of Piper nigrum will enhance the body's adsorption, of certain nutrients, such as those in the Niagra formula. Piper nigrum inclusion is to increase the speed at which the herbs start working and help with maximum herbal adsorption of the herbs, making the finished product more effective.
Epimedium Or Horny Goat Weed holds an important place in traditional Chinese medicine, now gaining popularity throughout the world for its role in restoring sexual life, boosting erectile function, allaying fatigue and depression.
Termed as most valuable herbal tonic, epimedium supports healthy sexual activity, helps boost libido and improve erectile function. It works by freeing up testosterones which are responsible for sex drive and endurance. It tones up kidneys and reduces symptoms of impotence, frequent urination and lower back pain.
Clinical researches prove that epimedium increase sexual activity, enhance sperm production and have a moderate androgen like influence on the testes, prostate gland and genital muscles thus influencing desire and interest for sexual activity.
Researches also show that Epimedium can inhibit an enzyme called acetylcholinesterase (AChE). By inhibiting AChE, Epimedium supports higher levels of the key cholinergic neurotransmitters associated with sexual arousal.
Trials prove that usage of epimedium elevates the levels of noradrenalin, adrenaline, serotonin and dopamine, thus encouraging release of LH which in turn stimulates testes to produce more testosterone. Also associated with stimulation of sensory nerves particularly genital region.